He aha ka S-4 (Andrarine)

S-4, kuai ma ke anoandarine, he mea hiki ke ola waha, non-steroidal selective androgen receptor modulator (SARM).ʻO Andarine kahi agonist ʻāpana o ka receptor androgen.

Ua hoʻomohala ʻia ʻo S-4 e like me nā SARMS ʻē aʻe i ka 2000s mua, i ka hoʻāʻo ʻana e lanakila i nā palena pharmacologic a me pharmacokinetic o nā agonists steroidal androgen receptor (ie, testosterone a me DHT), i ʻike i nā hui me ka ate a me ka maʻi puʻuwai.

Ua hoʻohana ʻia ʻo Compound S-4 i nā haʻawina holoholona akā ua haʻalele ʻia ma mua o nā hoʻokolohua lapaʻau kanaka Phase I, ma muli o nā hemahema ʻike.Loaʻa kēia mau hopena i ka hoʻopaʻa ʻana o ka mole S-4 i nā mea loaʻa i ka maka;ʻoi aku ka ʻoi aku o ka hoʻopaʻapaʻa ʻana, ʻoi aku ka nui o ka ʻeha i ʻike ʻia.Ua ʻike ʻia nā pilikia ʻike maʻamau, ma muli o ka hana mechanistic kūikawā, no ka lāʻau lapaʻau i haʻalele ʻia nā hoʻokolokolo.

PeheaS4Hana Andarine

ʻO kekahi o nā mīkini i manaʻo ʻia oS4, ʻo ia ka mea e poloka loa ai i ka hoʻopaʻa ʻana o DHT.ʻO Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone a stanolone) he hormone sex androgen endogenous.E pili ana i ka testosterone, ʻoi aku ka ikaika o DHT ma ke ʻano he agonist o ka mea hoʻokipa androgen.

Loaʻa iā S-4 kahi pilina hoʻopaʻa androgen kiʻekiʻe (AR).Ua hōʻike nā haʻawina he emi ka ikaika a me ka maikaʻi o ka S-4 ma mua o ka testosterone propionate (TP) i ka hana androgenic, akā ua like ka hana anabolic me ka TP.

ʻO S-4 kahi agonist receptor androgen piha i loko o ka ʻiʻo ʻiʻo, a he agonist ʻāpana i ka prostate.No laila, hoʻoulu ikaika ʻo S-4 i ka ulu ʻana o ka ʻiʻo, akā hiki ʻole ke mālama i ka nui o ka prostate.Hoʻoulu ka Testosterone i ka ulu ʻana o ka ʻiʻo a me ka prostate i ka nui like.S-4 ke kumu nui luteinizing hormone (LH) a follicle stimulating hormone suppression.

S-4 (andarine) Pono

ʻOiai ua nui nā noiʻi noiʻi i mālama ʻia, ʻoi aku ka nui o nā noiʻi e hoʻomau ʻia ana a i ka wā mua o ka hoʻomohala ʻana.ʻO ka hoʻomohala ʻana o SARMS no ka hoʻohana ʻana i ka lāʻau lapaʻau a me ka therapeutic ma ke ʻano he androgen alternative, ke hoʻohiki nei e pili ana i ka ʻikepili preclinical.

ʻAʻole like me nā steroid anabolic, e hoʻopaʻa ana i nā mea hoʻokipa androgen i nā ʻiʻo he nui ma ke kino holoʻokoʻa, hoʻopaʻa paʻa nā SARM pākahi i nā receptors androgen i kekahi mau kiko, akā ʻaʻole i nā mea ʻē aʻe.Eia nō naʻe, ke hōʻike nei lākou i nā hopena androgenic a anabolic.

ʻAʻole nā ​​SARMS i nā steroid anabolic;akā, he mau ligand synthetic lākou e hoʻopaʻa i nā mea hoʻokipa androgen.Ma muli o ko lākou ʻano mole, hana lākou ma ke ʻano he agonists, partial agonists, a me antagonists.No laila ma ke ʻano koho, ʻo SARMS e hoʻololi a i ʻole e hoʻoponopono i nā coregulators a me nā mea transcription a i ʻole ka hōʻailona ʻana i nā protein cascade e hāpai i ka hana anabolic.

Ua hōʻike ʻia nā haʻawina ʻo S-4 he agonist receptor androgen piha i loko o ka ʻiʻo ʻiʻo, a he agonist hapa i loko o ka prostate, e hoʻolilo iā ia i moho kūpono ma ke ʻano he ʻokoʻa i nā agonists androgen receptor agonists (ʻo ia hoʻi, testosterone a me DHT), ma muli o nā hopena ʻino. ma ke ake, naʻau, a me ka momona.

Pono e hoʻomaopopo ʻia, ʻoiai ʻo SARMS e like me S4 ​​e hoʻonui i ka hana androgen, ʻaʻole ia he moho kūpono no ka hormone replacement therapy, no ka mea, ʻaʻole ia e ʻono i loko o Estrogen.